心衰患儿红细胞内外钙离子浓度的变化及临床意义 心衰患儿红细胞内外钙离子浓度的变化及临床意义

The changes of intra and entracellular calcium concentrations in erythrocytes in children with heart failure and its clinical significances

目的：为了深讨心肌细胞内钙离子浓度的变化与心力衰竭发生的关系。方法：原子吸收分光技术测定红细胞内外Ca2+含量。我们对住院的56例心力衰竭患儿进行了红细胞内及血浆钙离子浓度的测定，并与30例正常小儿对照。结果：心衰患儿红细胞内Ca2+浓度明显升高，血浆Ca2+浓度降低，与对照组相比有非常显著性差异（P＜0．001）。其升高程度与心衰呈正相关（r=0．63，P＜0．01），即心衰越重，心功能越差，红细胞内Ca2+浓度升高亦越明显。而当心衰纠正，心功能恢复后，红细胞内Ca2+浓度则明显下降，血浆Ca2+浓度也恢复正常。而不同病因所致的心衰，其间红细胞内Ca2+浓度升高程度无明显差异。结论：提示钙离子参与了心力衰竭的发生与发展。

Objective:To probe into the possible relation of the changes in myocyte calcium concentration with heart failure, we measured calcium concentration in erythrocyte and in plasma of 56 patients with heart failure, and 30 healthy children were also determined as control.Methods: Measured calcium concentration in and outer of erythrocyte with the technique of afomic absorption spectrometry.Results: show that calcium concentration in erythrocyts increased but in plasma decreased in heart farlure group compared with those in control group (all P ＜ 0.001), there was a significant positive correlation between erythrocyte Ca2+ level with heart failure(r = 0.63, P ＜ 0.01). Patients with a worse cacdiac function had ahigher erythrocyte Ca2+ level. When the cardiac function improves, Ca2+ concentration in erythrocyte and in plasma trend tonormal. No significant difference in erythocyte Ca2+ concentration was observed among fifferent causes of heatt failure.Conclusion: Ca2+ may contribute to the occurence and development of heart failure.