川贝母生物碱类成分的研究

Alkaloid constituents of Fritillaria cirrhosa

目的对百合科植物川贝母Fritillariacirrhosa的干燥鳞茎进行化学成分研究。方法采用反复硅胶柱色谱进行分离纯化,根据理化性质和波谱数据鉴定化合物的结构。结果分离鉴定了8个生物碱类化合物,分别为川贝酮(chuanbeinone,Ⅰ)、梭砂贝母酮(delavinone,Ⅱ)、贝母乙素(pei minine,Ⅲ)、西贝素(i mperialine,Ⅳ)、petil-idine(Ⅴ)、贝母甲素(pei mine,Ⅵ)、贝母辛(pei misine,Ⅶ)、solanidine3-O-α-L-rhamnopyranosyl-(1→2)-[β-D-gluco-pyranosyl-(1→4)]-β-D-glucopyranoside(Ⅷ)。结论化合物Ⅰ、Ⅱ、Ⅳ、Ⅴ、Ⅷ为首次从本植物中分离得到。

Objective To study the chemical constituents in the bulbs of Fritillaria cirrhosa. Methods Chemical constituents were isolated with silica gel column chromatographic methods and their structures were elucidated on the basis of their physicochemical and spectral evidences. Results Eight compounds were isolated from F. cirrhosa and their structures were identified as chuanbeinone （ Ⅰ ）, delavinone （ Ⅱ ）, peiminine （ Ⅲ ）, imperialine （Ⅳ）, petilidine （ Ⅴ ）, peimine （ Ⅵ ）, peimisine （Ⅶ）, solanidine3-O-a-L-rhamnopyranosy1-（1→2）-β-D-gluco-pyranosyl-（1→4）]-1]-D-glucopyranoside（Ⅷ）. Conclusion Compounds Ⅰ、Ⅱ、Ⅳ、Ⅴ、 and Ⅷ are obtained from this plant for the first time.