福建省唇腭裂流行病学研究

An epidemiological survey of cleft lip and cleft palate in Fujian province

目的为了解福建省唇腭裂发病情况并分析致畸因素。方法对１９８６年１０月至１９９２年１２月６年内福建省２２所医院的出生缺陷监测资料进行唇腭裂发病情况的研究。结果在１３９８８２名新生儿中发现唇腭裂２０４例，福建省唇腭裂发病率为１．４６‰（１∶６８４），尚不属国内高发区。６年的年度发病率未见有明显的变化。２０４例唇腭裂中有２８例伴有其他系统畸形。结论本研究母亲年龄、孕次、产次对唇腭裂发生的影响作用不肯定；吸烟、接触有害物质及孕期用药等因素与唇腭裂发病率有重要关系。

Objective To find out the incidece of cleft lip and cleft palate in Fujian provice and to analysis the factors of its deformity.Methods From Oct. 1986 to Dec. 1992, the birth defect monitoring was carried out in 22 hospitals in Fujian province.Results It was found that there were 204 cases of cleft lip (CL) and cleft palate (CP) in 139 882 perinatals. The incidence rate of CL and/or CP was 1.46‰. Annual incidence rate of CL and/or CP had not found any significant change. Conclusion Among the 204 cases 28 had other deformities. The incidence rate of CL and/or CP related to maternal age, birth order, smoking factors were studied.