经皮二尖瓣球囊扩张术对血浆降钙素基因相关肽、内皮素失衡的影响

THE EFFECTS OF PERCUTANEOUS BALLOON MITRAL VALVULOPLASTY ON THE IMBALANCE BETWEEN PLASMIC CALCITONIN GENE RELATED PEPTIDE AND ENDOTHELIN

为探讨经皮二尖瓣球囊扩张术（ＰＢＭＶ）对血浆降钙素基因相关肽（ＣＧＲＰ）及内皮素（ＥＴ）的影响，采用放射免疫分析法（ＲＩＡ）测定了３０例二尖瓣狭窄（ＭＳ）患者经皮二尖瓣球囊扩张术前后血浆降钙素基因相关肽、内皮素水平。结果显示：１、ＰＢＭＶ前后血浆ＣＧＲＰ水平分别为３５．６０１±１７．２９４ｎｇ／Ｌ，３９．２４６±１８．５２８ｎｇ／Ｌ（Ｐ＞０．０５）；血浆ＥＴ分别为１１７．５２４±４０．６３１ｎｇ／Ｌ，９４．９４９±３１．７９９ｎｇ／Ｌ（Ｐ＜０．０５）；ＣＧＲＰ／ＥＴ分别为０．３０２±０．１４１、０．４５２±０．１６１。２、血浆ＣＧＲＰ水平与平均肺动脉压呈负相关（ｒ＝－０．４３５，Ｐ＜０．０５），而与血浆ＥＴ呈显著正相关（ｒ＝０．７３５，Ｐ＜０．００１）。研究表明，ＭＳ患者血浆ＣＧＲＰ／ＥＴ严重失衡，ＰＢＭＶ对恢复ＣＧＲＰ／ＥＴ间平衡有积极作用。

In order to study the effects of percutaneous balloon mitral valvuloplasty(PBMV)on the imbalance between plasmic calcitonin gene related peptide(CGRP)and endothelin (ET),the plasmic CGRP and ET levels of pre and post PBMV of 30 patients with mitral stenosis(MS) were monitored with radioimmunoassay.The results are as follows:1.The plasmic CGRP and ET contents of pre and post PBMV were 35.601±17.294ng/L,39.246±18.528ng/L( P >0.05)respectively;the ET level were 117.524±40.631ng/L,94.949±31.799 ng/L( P <0.05) respectively;CGRP/ET was 0.302±0.141,0.452±0.161 respectively.2.Plasmic CGRP level negatively correlated with mean pulmonary artery pressure(MPAP)( r =-0.435, P <0.05)and ET positively correlated with MPAP( r = 0.735 ,P <0.001).The results showed that there was serious imbalance between plasmic CGRP and ET.PBMV can improve significantly the imbalance.Monitoring plasmic CGRP and ET levels may be an important indicators in evaluating patient's condition and curative effects of PBMV.