ACE抑制剂福辛普利钠及关键中间体合成研究进展

Research Progress in Synthesis of Angiotensin-converting Enzyme Inhibitor Fosinopril Sodium and Key Intermediate

福辛普利钠是一种含次膦酸酯基的第三代血管紧张素转换酶抑制剂。本文着重评述了福辛普利钠以及关键中间体(反)-4-环己基-L-脯氨酸的合成方法,提出了易实现工业化制备福辛普利钠的合成工艺路线。

Fosinopril sodium containing phosphiny group was an angiotensin-conversion enzyme inhibitor in the third generation. The synthesis methods of fosinopril sodium and key intermediate （trans）-4-cyclohexyl-L-proline had been reviewed. It was suggested that the route for preparation of fosinopril sodium was easy to realize in- dustrialization.