期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

慢性应激损害大鼠信号逆反学习能力:一种新的T型水迷宫检测方法 被引量：2

下载PDF
导出
摘要 目的研究慢性应激对大鼠T型水迷宫线索学习和逆反学习能力的影响。方法大鼠经4周慢性不可预测应激后,利用本实验室创建的T型水迷宫装置,训练大鼠进行灯光信号-站台条件化学习直至达到设定的学习标准,然后进行逆反学习训练。结果应激组大鼠达到信号学习标准的学习次数为(30±2.81)次,与对照组[(32±2.98)次]的差异无统计学意义(P>0.05),但达到逆反学习标准的学习次数[(45±4.2)次]较对照组[(31±2.8)次]显著地增加,差异有统计学意义(P<0.05)。结论慢性应激对大鼠T型水迷宫线索学习和逆反学习产生不同的影响,应激明显损害了逆反学习任务的获得。
作者 王玮文 邵枫 刘美 金简 林文娟
机构地区 北京中科院心理所心理健康重点实验室 北京大学心理学系
出处 《中国神经精神疾病杂志》 CAS CSCD 北大核心 2009年第1期42-44,共3页 Chinese Journal of Nervous and Mental Diseases
基金 国家自然科学基金项目(编号:30500158,30670708) 中科院创新工程重要方向项目(编号:KSCX2-YW-R-131) 973项目(编号:2007CB512306)
关键词 慢性不可预测应激 T型水迷宫 线索学习 逆反学习
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献11

  • 1林涛,韩鸿宾,王丽颖,蔡焯基.首发抑郁症海马体积及影响因素研究[J].中国神经精神疾病杂志,2008,34(6):368-370. 被引量：9
  • 2Li Song, Wang Che, Wang MW, et al. Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress [J]. Pharmacol Biochem Beh, 2006, 83(2) : 186 - 193.
  • 3Girard TA, Wainwright PE. Testing the spatial- versus objectlearning distinction: water-maze performance of male rats exposed to ethanol during the brain growth spurt [ J 1. Beh Brain Res, 2002, 134(1 -2) : 493 -503.
  • 4Willner P. Validity, reliability and utility of the chronic mild stress model of depression : a 10-year review and evaluation [ J ]. Psychopharmacology, 1997, 134(4) :319 -329.
  • 5王玮文,林文娟.一种动物学习能力的行为测试用水迷宫.中国,专利申请号:200520142005.4.
  • 6曹莉萍,李涛,刘协和.海洛因依赖与多巴胺D_2受体基因的关联分析[J].中华精神科杂志,2003,36(1):31-33. 被引量：16
  • 7Schrijver NC, Pallier PN, Brown VJ, et al. Double dissociation of social and environmental stimulation on spatial learning and reversal learning in rats[J]. Beh Brain Res, 2004, 152(2) : 307 -314.
  • 8Sehoenbaum G, Nugent S, Saddoris MP, et ah Teaching old rats new tricks: Age-related impairments in olfactory reversal learning [J]. Neurobiology of Aging, 2002, 23(4): 555-564.
  • 9Ferry AT, Lu X, Price JL. Effects of excitotoxic lesions in the ventral striatopallidal-thalamocortical pathway on odor reversal learning : inability to extinguish an incorrect response [ J ]. Exp Brain Res, 2000, 131(3) : 320 -335.
  • 10McAlonan K, Brown VJ. Orbital prefrontal cortex mediates reversal learning and not attentional set shifting in the rat [ J ]. Beh Brain Res, 2003, 146(1): 97-103.

二级参考文献19

  • 1谢守付,马慧,刘伟,彭淼,丁宝坤.抑郁症模型鼠海马神经元细胞凋亡的初步研究[J].中国神经精神疾病杂志,2004,30(5):342-345. 被引量：6
  • 2杨朋范,落合卓,林基弘,山根文孝,堀智胜.人体海马及杏仁核体积的MRI测定[J].中国临床神经外科杂志,2005,10(5):327-330. 被引量：9
  • 3Lachner G, Satzger W, Engel RR. Verbal memory tests in the differential diagnosis of depression and dementia: Discriminative power of seven test variations. Arch Clin Neuropsychol, 1994, 9(1): 1.
  • 4Petersen RC, Smith GE, Ivnik R J, et al. Memory function in very early Alzheimer's disease. Neurology, 1994, 44(5): 867.
  • 5Backnan L, Andersson JL, Nyberg L, et al. Brain regions associated with episodic retrieval in normal aging and Alzheimer's disease. Neurology, 1999, 10, 52(9): 1861.
  • 6Van der Flier WM, Van den Heuvel DMJ, Weverling-Rijnsburger AWE,et al. Cognitive decline in AD and mild cognitive impairment is associated with global brain damage. Neurology, 2002, 59(6):874.
  • 7Ilsley JE, Moffoot APR, O'Carroll RE. An analysis of memory dysfunction in maj or depression. Journal of Affective Disorder, 1995, 35(1): 1.
  • 8Austin MP, Mitchell P, Goodwin GM. Cognitive deficits in depression:possible implications for functional neuropathology. Br J Psychiatry,2001, 178(3):200.
  • 9Schatzberg AF, Posener JA, Charles Debattista, et al. Neuropsychological deficits in psychotic versus nonpsychotic major depression and no mental illness. Am J Psychiatry, 2000, 157(7): 1095.
  • 10Fossati P, Guillaume LB, Eegis AM et al. Qualitative analysis of verbal fluency in depression. Psychiatry Research, 2003, 117(1): 17.

共引文献31

同被引文献20

  • 1马行,库宝善,姚海燕,徐英.对抑郁模型小鼠强迫游泳实验方法的探讨[J].徐州医学院学报,2005,25(3):230-233. 被引量：18
  • 2Zhou jiansong,Li lingjiang,Tang saojun,et al.Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation[J].Behav Brain Res.2008,195(1):129-38.
  • 3McEwen BS,Chattarji S.Molecular mechanisms of neuroplasticity and pharmacological implications:the example of tianeptine[J].Eur Neuropsychopharmacol,2004,14(5):497-502.
  • 4Robertson DA,Beattie JE,Reid IC,et al.Regulation of corticosteroid receptors in the rat brain:the role of serotonin and stress[J].Eur J Neurosci,2005,21(6):1511-1520.
  • 5Kornum BR,Licht CL,WeikopP,et al.Central serotonin depletion affects rat brain areas differently:a qualitative and quantitative comparison between different treatment schemes[J].Neurosci Lett,2006,392(1-2):129-134.
  • 6Sala M,Perez J,Soloff P,et al.Stress and hippocampal abnormalities in psychiatric disorders[J].Eur Neuropsychopharmacol,2004,14(5):393-405.
  • 7Ridder S,Chourbaji S,Hellweg R,et al.Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions[J].J Neurosci,2005,25(26):6243-6250.
  • 8Schulte-Herbruggen O,Chourbaji S,Ridder S,et al.Stress-resistant mice overexpressing glucocorticoid receptors display enhanced BDNF in the amygdala and hippocampus with unchanged NGF and serotonergic function[J].Psychoneuroendocrinology,2006,31(10):1266-1277.
  • 9Porsolt RD, Lc Pichon M, Jalfrc M. Depression: a new animal mod- el sensitive to antidepressant treatments [J]. Nature, 1977, 266: 730-732.
  • 10Petit-Demouliere B, Chenu F, Bourin M. Forced swimming test in mice: a review of antidepressant activity [J]. Psychopharmacology (Berl), 2005, 177: 245-255.

引证文献2

二级引证文献9

中国神经精神疾病杂志
2009年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部