狼疮肾炎热瘀证与临床病理的相关性研究

Study on Correlation of Heat-blood Stasis Syndrome with Clinical Pathology in Lupus Nephritis Patients

目的:研究狼疮肾炎热瘀证与临床及肾脏病理损害的相关因素分析。方法:分析30例狼疮肾炎热瘀证与30例狼疮肾炎非热瘀证的临床及肾脏病理资料。结果:狼疮肾炎热瘀证多见于SLE活动期,热瘀证组抗dsDNA阳性率、SLEDAI积分明显高于非热瘀证组(P<0.01),而补体C3、C4明显低于非热瘀证组(P<0.01);除血浆tPA含量外,血浆纤维蛋白原(FIB)、D-二聚体、1型纤溶酶原激活物抑制物(PAI-1)含量在两组病人间存在统计学差异,热瘀证组明显高于非热瘀证组(P<0.01～0.05);热瘀证组肾脏病理的活动积分显著高于非热瘀证组;热瘀证组肾组织纤维蛋白原相关抗原(FRA)沉积程度明显强于非热瘀证组。结论:狼疮肾炎热瘀证与临床及病理损害有一定相关性,狼疮肾炎热瘀证与狼疮活动、肾脏病理活动、全身及肾脏局部高凝和纤溶低下有一定相关。

Objective：To observe the relationship between heat -blood stasis syndrome（HBSS）and clinical pathology in patients with lupus nephritis （LN）. Methods： We collect the clinical pathological materials of 30 patients with HBSS, and 30 patients with non heat - blood stasis syndrome （non HBBS）. Results：Patients with HBSS were often seen at the active stage and accompanied with hypocomplementemia, positive of A - dsDNA antibody and high SLEDAI. Compared with patients of non blood stasis syndrome, the values of plasma fibrinogen （FIB）and D- dimer（ D - D） in HBSS patients were obviously higher （P 〈 0.05 ）, active index of renal pathology significantly higher, and degrees of fibrinogen - related antigen （FRA） deposited in renal tissues more severe. Conclusion： HBSS of LN was related to certain extent with clinical pathological changes such as SLE activity, active index of renal pathology, high coagulation and low fibrinolysis.