摘要
雄激素受体(AR ) 在前列腺癌症(PCa ) 的发展和前进起一个重要作用。雄激素剥夺治疗在堵住肿瘤生长是开始有效的，但是它最后导致荷尔蒙倔强的状态。到雄激素独立的从雄激素依赖的变换的详细机制仍然保持不清楚。几根 PCa 房间线被建立在 PCa 学习 AR 的角色，但是结果经常在不同房间线，或在在不同条件下面种的一样的房间线不一致或对比。上皮的房间和他们的微型环境的细胞、分子的改变是复杂的，并且使用一根单个房间线处理这个重要问题是困难的，也，到学习， pathophysiological AR 完成。在这份报纸，我们在使用一个单个人的 PCa 房间的劣势衬里在 PCa 上学习 AR 效果的多重房间线和表演上总结 AR 的不同效果。我们也讨论广泛地使用的上皮鈥搒t roma 合作文化系统，异种皮移植老鼠模型，和遗传上设计的 PCa 老鼠模型的优点。联合在 vitro 房间线研究并且在 vivo，老鼠模型可能在 PCa 为 AR 角色的学习导致更可信的结果和更好的策略。
The androgen receptor （AR） plays an important role in the development and progression of prostate cancer （PCa）. Androgen deprivation therapy is initially effective in blocking tumor growth, but it eventually leads to the hormonerefractory state. The detailed mechanisms of the conversion from androgen dependence to androgen independence remain unclear. Several PCa cell lines were established to study the role of AR in PCa, but the results were often inconsistent or contrasting in different cell lines, or in the same cell line grown under different conditions. The cellular and molecular alteration of epithelial cells and their microenvironments are complicated, and it is difficult to use a single cell line to address this important issue and also to study the pathophysiological effects of AR. In this paper, we summarize the different effects of AR on multiple cell lines and show the disadvantages of using a single human PCa cell line to study AR effects on PCa. We also discuss the advantages of widely used epithelium-stroma co-culture systems, xenograft mouse models, and genetically engineered PCa mouse models. The combination of in vitro cell line studies and in vivo mouse models might lead to more credible results and better strategies for the study of AR roles in PCa.
