肝移植动物模型的研究现状和评价

Current situation of animal models for orthotopic liver transplantation

肝移植作为治疗终末期肝病的新型治疗方式已取得了瞩目的进展。动物模型在肝移植研究的发展过程中起至关重要的作用。但不同的动物模型之间存在差异,各种不同的局限性使其不能完全模仿人类临床状态。正确选择及应用各种动物的特点,建立和改进各种动物模型,是肝移植术研究发展的基础。

Liver transplantation, as a new treatment for terminal-stage liver diseases, has made remarkable strides in the past decades. Animal models play an essential part in liver transplantation research, but differ from one another and have different limits to be used in imitating human clinical conditions. Therefore, it is the base for the development of liver transplantation to build and improve animal models by correctly selecting and utilizing different characteristics of different animals.