有机磷杀虫剂的免疫毒性及其机制的研究进展

Organophosphorus pesticide-induced immunotoxicity and its updated mechanisms

有机磷杀虫剂(OP)在世界范围内广泛用于防治植物病、虫害,它对人和动物的主要毒性来自抑制乙酰胆碱酯酶引起的神经毒性,同时还具有免疫毒性,影响免疫应答,抑制抗体产生和T细胞增殖,增加自身抗体,抑制自然杀伤(NK)细胞、细胞毒性T淋巴(CTL)细胞的活性。国内对有机磷杀虫剂免疫毒性机制的研究,尤其是对其抑制NK细胞溶细胞活性的机制研究还很少。现就国外关于OP的免疫毒性及其机制的研究进展作一综述。

Organophosphorus pesticides （OP） are used as insecticides in agriculture throughout the world. The main toxicity of OP is neurotoxicity, which is caused by the inhibition of acetylcholinesterase. OPs also affect the immune response and suppress antibody production, T cell proliferation and the activity of natural killer （NK） cells and cytotoxic T lymphocytes （CTL）. However, there have been few studies on the mechanism of OP-induced immunotoxicity, especially the mechanism of OP-induced inhibition of the cytolytic activity of killer cells. This study updates the mechanisms of pesticide-induced immunotoxicity, including its direct and indirect effects on the immune system.