实体瘤微环境的特点及治疗策略

The characteristics and treating strategy on the micro-environment of solid tumor

实体瘤的发生和发展是多因素、多步骤和多基因共同作用的过程。肿瘤微脉管系统的生成及其与微环境之间的相互作用决定了肿瘤生长、复发、侵袭和转移的生物学特性。合理选择抗血管生成药物的治疗能使肿瘤脉管系统正常化,提高化疗和放疗的疗效,从而延长患者生存时间。

The occurrence and development of solid tumor is a multi-factor, multi-step and multi-gene interactive process. The generation of micro vasculature of solid tumor, as well as the interaction between tumor and micro-environment, decides the tumor＇ s biological characteristics of growth, recurrence, invasion and metastasis. Reasonable application of anti-angiogenesis therapy enables the normalization of tumor vascular system to enhance the efficiency of chemotherapy and radiation treatment and prolong survival time in patients.