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γ-H2AX与肿瘤治疗 被引量：2

γ-H2AX and Tumor Treatment
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摘要 DNA双链断裂后可诱导位于丝氨酸-139位C端保守区域内的H2AX磷酸化形成γ-H2AX，组蛋白H2AX在DNA损伤修复、细胞周期检查点调控、基因组稳定的维持和肿瘤抑制中起着重要作用。随着研究的不断深入，其在医学中的应用将越来越广泛。 DNA double-trandbreaks （DSB） could induce phosphorylation of H2AX at eonservative Cterminal region of serine 139 and the formation of γ-H2AX. Histone H2AX has been proved to play an important role in DNA repair, cell eyele eheekpoints, genornie stability and tumor suppression. With the in-depth study,its application will be more and more widely in medicine.
作者 柴翠青（综述） 孙青（审校）
机构地区 泰山医学院 山东省千佛山医院病理科
出处 《医学综述》 2009年第3期350-352,共3页 Medical Recapitulate
关键词 组蛋白H2AX 肿瘤 治疗 Histone H2AX Tumor Treatment
分类号 R73 [医药卫生—肿瘤]
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  • 1Harsha HC, Suresh S, Amanchy R,et al. A manually curated functional annotation of the human X chromosome [ J ]. Nat Genet, 2005,37(4) :331-332.
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  • 3Redon C, Pilch D, Rogakou E ,et al. Histone H2A variants H2AX and H2AZ[J]. Curt Opin Genet Dev,2002,12(2) :162-169.
  • 4Wang H, Wang M L, Wang HC,et al. Complex H2AX phosphorylation pattern by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors [ J ]. Cell Physiol,2005,202 ( 2 ) :492-502.
  • 5Rogakou EP, Boon C, Redon C ,et al. Megabase chromatin domains involved in DNA double-strand breaks in vivo[ J]. Cell Biol, 1999, 146(5 ) :905-915.
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  • 8Stiff T,O'Driscoll M,Rief N ,et al. ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation[ J]. Cancer Res ,2004,64(7 ) :2390-2396.
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医学综述
2009年 第3期

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