哮喘患者血液中ET、TXB2、6-K-PGF-1α检测的临床意义

Clinical Signficance of Detection on ET、TXB2 and 6-K-PGF-1α Levels in Patients′Blood with Asthma

目的测定哮喘病情严重程度不同的患者血液中的内皮素（ET）、血栓素B2（TXB2）、6-酮-前列腺素（6-K-PGF-1α）的水平，以探讨其在哮喘中的监测意义及相互作用。方法共选择轻度哮喘组患者32例，中重度哮喘组患者23例，健康对照组共18例，每例研究对象抽取清晨空腹静脉血5mL。将其分为2部分，其中3mL用于测定TXB2、6-K—PGF1α；2mL用于测定ET。数据统计分析采用单因素方差分析。结果①三组血浆中ET水平比较：轻度哮喘组与中重度哮喘组高于健康对照组，差异有统计学意义（P〈0．01），轻度哮喘组低于中重度哮喘组，差异有统计学意义（P〈0．01）。②三组血浆中6-K—PGF1α水平比较：轻度哮喘组与中重度哮喘组低于健康对照组，差异有统计学意义（P〈0．01），轻度哮喘组高于中重度哮喘组，差异有统计学意义（P〈0．01）。③三组血浆中TXB，水平比较：轻度哮喘组与中重度哮喘组高于健康对照组，差异有统计学意义（P〈0．01），轻度哮喘组低于中重度哮喘组，差异有统计学意义（P〈0．01）。结论ET、TXB2与哮喘的病情严重程度呈正相关，并可能在气道炎症方面影响哮喘的发生、发展。6-K—PGF1α与哮喘的病情呈负相关，说明是机体的一种保护机制。

Objective Test the level of ET,TXB2 ,6-K-PGF-1α in patients, blood with different severity sthma,explore their monitoring significance and interaction in asthma. Methods Select 32 patients in mild asthma group,23 patients in moderate-severe asthma group, 18 patients in healthy control group. Each case drew 5 ml limosis veinal blood and the blood was divided into 2 parts：3 ml is used to determine TXB2 ,6-K-PGF-1-alpha; 2ml is used to determination of ET. Statistical analysis use single-factor variance analysis. Results （1）The levels of ET in plasma of mild asthma and moderate-severe asthma group are higher than that in healthy control group, the difference is statistically significant （P 〈 0.01 ）. The levels, of ET in plasma of mild asthma group is lower than that in moderate-severe asthma group,and the difference is statistically significant（ P 〈 0.01 ）. （2）The levels of 6-K-PGF-1 alpha in plasma of mild asthma and moderate-severe asthma group are lower than that in the control group, the difference is statistically significant（ P 〈0. 01 ）. The levels of 6-K-PGF-1 alpha in plasma of mild asthma group is higher than that in moderate-severe asthma group, the difference is statistically significant（ P 〈 0.01 ）. （3）The levels of TXB2 in plasma of mild asthma group and moderate-severe asthma group are higher than that in control group, the difference is statistically significant （ P 〈 0.01 ）. The levels of TXB2 in plasma of mild asthma group is lower than that in moderate-severe asthma group, the difference is statistically significant （P 〈 0. 01 ）. Conclusion ET and TXB2 are positively correlated to asthma severity, have the possibility to influece asthma occurrence and development in airway inflammation. 6-K-PGF-1 alpha is negatively correlated to asthma, is a protection mechanism in body.