多烯磷脂酰胆碱治疗乙醇性脂肪肝24例疗效观察

Therapeutic Effect of Polyene Phosphatidylcholines on 24 Cases with Alcoholic Fatty Liver

目的观察多烯磷脂酰胆碱治疗乙醇性脂肪肝的临床疗效。方法48例乙醇性脂肪肝患者均戒酒，随机分为治疗组24例和对照组24例。治疗组给予多烯磷脂酰胆碱注射液465mg/d，对照组用复方甘草酸苷注射液80mL／d，疗程均为4周。结果治疗组患者临床症状明显消失，肝功能及B超检查明显好转，与对照组比较，差异有统计学意义（P〈0．01）。结论多烯磷脂酰胆碱能改善乙醇性脂肪肝患者临床症状、肝功能，疗效优于复方甘草酸苷。

Objective To investigate the clinical therapeutic effect of polyene phosohatidylcholine on patients with alcoholic fatty liver. Methods 48 cases with alcoholic fatty liver stopping drinking were randomly divided into therapeutic group （24 cases） and control group（ 24 cases）, the therapeutic group was given polyene phosohatidylcholine （ 465mg/day ） for 4 weeks, and control group （ 24 patients ） was given compound glycyrrhizin （ 80 ml/day） for 4 weeks. Results Clinical manifestation was disappeared in therapeutic group, and liver function and B-ultrasound result were also promoted obviously. These are all have statistic significance compared with that of control group（P 〈 0.01 ）. Conclusion Polyene phosohatidylcholine can improve the liver function of patients with alcoholic fatty liver. The clinical therapeutic efficacy of polyene phosohatidylcholine is superior to compound glycyrrhizin.