慢性睡眠剥夺对初诊2型糖尿病患者糖化血红蛋白的影响

Effect of chronic sleep deprivation on glycosylated hemoglobin in newly diagnosed patients with type 2 diabetes mellitus

目的观察慢性睡眠剥夺对糖尿病患者血糖控制的影响。方法对172例初诊糖尿病患者进行睡眠问卷调查,符合入选试验条件者75例,分为慢性睡眠剥夺组(A组36例)、正常睡眠时间组(B组25例)和超长时间睡眠组(C组14例),均进行强化治疗达标,之后除继续糖尿病饮食、运动外,据个体情况采用口服药或胰岛素治疗,分别检测强化治疗结束后3,6,9个月的糖化血红蛋白(HbA1c),观察各组的变化。结果A组HbA1c逐渐增高,C组亦呈上升趋势,而B组则平稳下降。结论慢性睡眠剥夺使HbA1c增高,睡眠时间超长,对HbA1c也有不利影响,在临床工作中应予以重视。

Objective It is to observe the effect of chronic sleep deprivation on the control of glucose in patients with type 2 diabetes. Methods 172 newly diagnosed patients with type 2 diabetes were given investigation about their sleep habit, in whom 75 patients consistent with the trial qualifications were selected as group A （n = 36）, group B （n = 25）, group C （n = 14）. All the patients were given intense treatment consequently to reach the goal. After that, diabetic diet, proper exercises as well as oral administration or insulin injection aiming directly at individuals were required. The results of HbAlc among three groups were determined and compared after 3, 6, 9 months＇ intense treatment. Results The HbAlc of group A and group C were increased, and that of group B decreased steadily. Conclusion Chronic sleep deprivation can increase HbAlc, and abnormal long-time sleep also has negative effects on HbA1c in the patients with type 2 diabetes, so we should pay more attention to this phenomenon.