克汀病人神经系统、骨损伤的临床表现及机制探讨

MANIFESTATION AND MECHANISM OF DAMAGED NERVOUS SYSTEM AND BONE IN ENDEMIC CRETINISM

本文对４２例克汀病人进行了全面检查，结果表明：克汀病患者发育滞后，瞳距增大，性发育滞后，多数病人出现聋哑；锥体和锥体外系受损出现生理反射亢进，病理反射阳性征。眼外肌麻痹等体征，主要见于神经型；脑ＣＴ显示：颅内钙化率增高、脑沟池增宽、脑室扩大。神经系统损伤部位有较强的选择性，脑发育不良导致精神发育迟滞。严重的骨骼发育障碍，呈多关节畸形，如膝关节。

In order to study mechanism of damaged nervous system and bone in cretin,42 cases in area of Baicheng county,Xinjiang was examined. Results showed that growth developing was backwords ard, Sexuality developing was retarded,deafmute was caused by severe injury of acoustic nerve. Many sign positive pathological reflex, unstable status step,hypertonic muscle were usually seen in nervous cretin. Results of CT demonstrated that calification rate in cranial cavity was higher than control,cerebral bitch and cistern were widen. Cerebral ventricle were enlarge, joint deformation could be seen major in knee:X leg or O leg.