夫精宫腔内人工授精临床妊娠率影响因素的研究

Related factors on pregnancy rate of artificial insemination by husband's sperm

目的探讨夫精宫腔内人工授精(AIH)的临床妊娠率与其影响因素的关系。方法64例不孕症患者分为自然周期(NC)组16例、克罗米芬-人绝经期促性腺激素-人绒毛膜促性腺激素(CC)组16例、人绝经期促性腺激素-人绒毛膜促性腺激素(HMG)组51例,共实施AIH 83个周期。结果总周期临床妊娠率14.5%。NC组、CC组、HMG组的临床妊娠率和HCG注射日尿LH阳性率分别为6.25%、18.75%、15.68%和87.5%、31.25%、52.9%,三组间尿LH阳性率差异有统计学意义(P<0.01);HCG注射日子宫内膜呈B型的临床妊娠率高于A型及C型;随着年龄增长,AIH临床妊娠率下降;不同授精时间妊娠率有不同。结论授精时间、a级精子活力、子宫内膜形态/厚度及女方年龄与AIH的临床妊娠率密切相关。

Objective To investigate the relationship between the pregnancy rate of artificial insemination by husband＇s sperm （AIH） and its related factors. Methods 64 infertility couples were divided into 3 groups - nature cycle （ NC）, clomiphene acide （CC） and human menopausal gonadotropin （HMG）. They were performed for 83 AIH cycles. Results Pregnancy rate was 14.5% ; pregnancy rate and ULH positive rate were respectively 6.25%, 18.75%, 15.68% and 87.5%, 31.25%, and 52.9%, ULH positive rate had significant difference among 3 groups （P 〈0.01 ） ; pregnancy rate of endometrian B was higher than that A and C; with the growing of female age, pregnancy rate was falling; different insemination time also made different prengnancy rate. Conclusion Insemination time, class a sperm ratio, endometrium thickness/pattern and female age have close relation with the pregnancy rate of AIH.