心肌酶生化指标对急性胰腺炎患者病情及预后的评估价值

The predictive value of myocardial enzyme in assess severity and prognosis of acute pancreatitis

目的了解心肌酶生化指标对急性胰腺炎患者病情判断及预后评估的意义。方法对306例急性胰腺炎患者的临床资料进行回顾性分析,分析其心肌酶生化指标天门冬氨酸氨基转移酶(AST)、羟丁酸脱氢酶(LBDH)、乳酸脱氢酶(LDH)与肌酸肌酶(CK)与疾病的严重度及预后关系。结果急性胰腺炎轻症组与重症组的心肌酶指标均升高,两组之间比较,重症胰腺炎患者组较轻症胰腺炎患者组升高明显(P<0.001或0.05)。除AST指标外,LBDH、LDH与CK指标均与预后相关(P<0.01或0.05),LBDH、LDH与CK指标升高者的预后相对较差。结论心肌酶生化指标LDH、CK及HBDH的测定有助于早期发现急性胰腺炎患者心肌损伤,对于判断病情的严重度及预后有重要的参考价值。

Objective To evaluate the clinical significance of myocardial enzyme in patients with acute pancreatitis. Methods 306 patients with a first acute pancreatitis （AP） were retrospectively analyzed. The relationship between the changes of myocardial enzyme and clinical severity and prognosis of AP were studied. Results The levels of myocardial enzyme （ AST, LDH, LBDH and CK） in severe acute pancreatitis group （SAP） were significantly increased compared with MAP （ P 〈 0.01 or 0.05 ）. The changes of myocardial enzyme （ LDH, CK and HBDH） were relative to the prognosis of acute pancreatitis （ P 〈 0.05 ）. Conclusion The changes of myocardial enzyme are definitely relative to the severity and prognosis of acute pancreatifis. Myocardial enzyme appears to be an early predictor of Heart damage in AP.