纳络酮治疗中重度新生儿缺氧缺血性脑病30例疗效分析

Naloxone for treating severe neonatal hypoxic ischemic encephalopathy in 30 cases

目的探讨纳络酮治疗中重度新生儿缺氧缺血性脑病(HIE)的临床疗效。方法将58例中重度HEI患儿随机分为治疗组和对照组,治疗组30例患儿在传统治疗基础上加用纳络酮(0.05～0.1mg/kg)治疗4～7d,对照组28例采用传统治疗方法。比较两组患儿主要症状、体征消失时间及意识、反射、肌张力恢复时间。结果治疗组患儿主要症状、体征消失时间短于对照组,总有效率达到90.0%,而对照组为67.9%。治疗组意识、反射、肌张力恢复时间比对照组平均缩短了3.45d,两组比较,差异有统计学意义(P<0.01)。两组不同时间神经行为评分比较,治疗组明显高于对照组,差异有统计学意义(P<0.05)。结论中重度HIE在传统治疗基础上加用纳络酮治疗可提高疗效,未见不良反应发生。

Objective To evaluate the curative effect of naloxone in the treatment of severe neonatal hypoxic ischemic encephalopathy （HIE）. Methods Fifty-eight patients were randomly divided into the treatment and control group. The treatment group （30 cases） was treated with the traditional treatment based on the use of naloxone（0.05-0. 1 mg/kg） for 4-7d,and the control group（28 cases） was treated with the traditional treatment. To comparing the disappearing time of the main symptoms and signs, and the recovery time of sense,reflection and muscle tone. Results The disappearing time of the main symptoms and signs in the treatment group was shorter than that of the control group. The total effective rate reached 90.0% for the treatment group and 67.9 % for the control group. The recovery time of sense reflection and muscle tone in the treatment group shortened by 3.45d compared with the control group. The difference had statistical significance（P〈0.01）. The different times for acts score was higher in the treatment group than the control group with statistical significance（P〈0.05）Conclusion Moderate to severe hypoxic.ischemic encephalopathy in the traditional treatment based on the use of naloxone can improve the efficacy of treatment, no side effects occur.