摘要
目的探讨白细胞介素(IL)6、8及肿瘤坏死因子(TNF-α)等细胞因子在病毒性心肌炎预后中的意义。方法对确诊为病毒性心肌炎患儿及健康对照组进行白细胞介素6、8和肿瘤坏死因子检测。结果急性期TNF-α、IL-6和IL-8水平明显高于恢复期与对照组,差异有统计学意义(P<0.01);恢复期较急性期下降,但仍高于对照组,差异无统计学意义(P>0.05);IL-8恢复较慢。结论IL-6、IL-8与TNF-α共同参与病毒性心肌炎的发病及病理变化过程,IL-8可作为判断小儿病毒性心肌炎预后的指标。
Objective To study the effect of interleukin 6（IL-6） ,interleukin-8（IL-8） and tumor necrosis factor alpha（TNF-α） in the prognosis of viral myocarditis. Methods To detect IL-6 ,IL 8 and TNF-α in the children patients with viral myocarditis and control group. Results The serum level of IL-6,IL-8 and TNF-α in acute stage was significant increased than that of convalescence stage（P〈0.01） ,but there was no significant difference between convalescence stage and normal control group（P〉0.05） ,although the level of IL-8 slowly decreased in convalescence stage. Conclusion IL-6 ,IL-8 and TNF-α take part in pathogeny and pathology of viral myocarditis. The level of IL-8 serum might he the prognostic marker of child viral myocarditis.
出处
《重庆医学》
CAS
CSCD
北大核心
2009年第2期163-163,166,共2页
Chongqing medicine
关键词
心肌炎
白细胞介素6
白细胞介素8
肿瘤坏死因子
预后
viral myoearditis
interleukin-6
interleukin-8
tumor necrosis factor alpha
prognosis
