马来酸曲美布汀联合双歧杆菌治疗功能性肠胀气疗效观察

Efficacy of trimebutine maleate combined with bifidobacterium in treatment of patients with overful gas in intestinal tract

目的观察马来酸曲美布汀联合双歧杆菌对功能性肠胀气的疗效。方法将功能性肠胀气患者随机分为A、B两组,每组30例。A组服用马来酸曲美布汀联合双歧杆菌,B组仅服用双歧杆菌,疗程2周。结果治疗1周,A组症状积分明显下降(P<0.01),B组无明显变化(P>0.05)。治疗2周,A组症状积分下降更为明显(P<0.01),B组较治疗前明显下降(P<0.05),但高于A组(P<0.05)。A组总有效率明显高于B组(1周有效率:腹胀:53.3%VS 17.9%,伴随症状:58.3%VS 28.6%;2周有效率:腹胀:76.7%VS 42.9%,伴随症状:79.2%VS 45.5%)。结论马来酸曲美布汀联合双歧杆菌对功能性肠胀气有较好疗效。

Objecctive To evaluate the efficacy of trimebufine mateate combined with bifidobactefittm in treatment of ovefful gas in intestinal tract of patients with alimentray dyskinesia.Methods By using a randomized and controlled clinical trial,the patients were divided into trimebutine maleate combined with bifidobacterium group（A group, n = 30）and bifidobacterium group（B group, n = 30） . The treaanent duration was 2 weeks.Results The symptom scores in A group decreased significanfly（ P 〈 0.01 ）after 1 week treatment and more remarkably（ P 〈 0.01）after 2 weeks treatment. In B group, tire symptom scores decreased significantly（ P 〈 0.05）only after 2 weeks treatment, and higher than A group（ P 〈 0.05）. Total efficacy rate of A group were higher than B group（ 1^st week efficacy rate： abdominal distension： 53.3% VS 17.9% .other symptoms： 58.3% VS 28.6% .2^nd week efficacy rate： abdomihal distension： 76.7% VS 42.9 %, other symptoms： 79.2 % VS 45.5 % ）. Conclusion Trimebutine maleate combined with bifidobactefium is effective in treatment of patients with overful gas in intestinal tract.