不同疗程阿奇霉素对支原体肺炎复发的阻碍作用

Different treatment of mycoplasma pneumonia azithromycin recurrence of the obstacles

目的观察应用阿奇霉素不同疗程治疗支原体肺炎对其复发的阻碍作用。方法，将108例2004年9月-2007年10月在我院儿科住院的支原体肺炎患儿随机分为观察（A）组58例和对照（B）组50例。分别使用阿奇霉素，A组10mg／（kg·d），服3d停4d，连续4～6周；B组10mg／（kg·d），连服5—7以结果两组患儿的入院后病程及临床症状和体征缓解或消失的时间，差异均无统计学意义（P〉0．05）。但是，2个月后复查胸片示：A组患儿胸片正常率远高于B组患儿，差异有统计学意义（P〈0．05）；3—6个月复发率：A组低于B组，6～12个月复发率：A组明显低于B组，差异有统计学意义（P〈0．01）；两组均无明显不良反应。结论间断重复使用阿奇霉素4—6周较连续应用阿奇霉素5～7d对再次复发的阻碍作用更佳。

Objective Observation of azithromycin different course of treatment recurrenee of mycoplasma pneumonia hinder its role.Methods 108 cases from September 2004 to October 2007 in our hospital paediatric hospital mycoplasma pneumonia were randomly divided into two groups （A）58 cases and the control group （B）50 cases,respectively,the use d azithromycin-（A） group of 10 mg/（kg · d） .four-day stop serving three consecutive 4 - 6 weeks（ B） Seetion 10 mg/（kg·d） ,and even served 5 - 7 days.Results The children were admitted to hospital after the disease and clinical signs and symptoms ease or disappear in time,there was no significant difference （P 〉 0.05）.However,the review in February after chest radiography showed group A patients with normal chest radiograph was much higher than group B patients, a significant difference（ P 〈 0.05）from March to June recurrence rate in group A than in group B,6-Deeember relapse rate in group A was significantly lower than that ingroup B, there were significant differences（ P 〈 0.01） ; There were no obvious adverse reactions. Conclusions Intermittent repeated use of azithromycin than 4-6 weeks of azithromycin 5-7 consecutive days again recurrence impeded better.