盐酸坦索罗辛治疗输尿管下段结石的临床疗效

Clinical effects of tamsulosin on patients with lower ureteral stones

目的评价α1受体阻滞剂盐酸坦索罗辛治疗输尿管下段结石的临床疗效。方法70例输尿管下段结石患者随机分为两组各35例,对照组口服非甾体类抗炎药塞来昔布胶囊(西乐葆)100mg2次/d;实验组口服西乐葆100mg2次/d及盐酸坦索罗辛0.4mg1次/d。随访4周评估两组间结石排出率、结石排出时间、肾绞痛发生次数及药物副作用。结果实验组和对照组结石完全排出率分别为85.7%(30/35)和57.1%(20/35),总有效病例实验组为32例,对照组为24例,两组比较差异有统计学意义(P<0.05);实验组排石时间、肾绞痛发生次数明显少于对照组,差异具有统计学意义(P<0.05);两组病例均未出现明显药物副作用。结论盐酸坦索罗辛有效促进输尿管下段结石的排出,并显著减少排石过程中肾绞痛的发生。

Objectives To evaluate the clinical effects of the alpha 1 - blocker - tamsulosin on patients with lower ureteral stones. Methods A total of 70 patients with the stones （4 - 10mm in diameter） located in the lower ureter were randomly divided into 2 groups （ 35 cases in the each group）. Control group accepted celecoxib capsule （ 100mg, bid daily）, and experimental group accepted celecoxib capsule （ 100mg, bid daily） and tamsulosin （0.4mg, once daily）. All patients were followed up for 4 weeks. Results During 4 weeks expulsion of the stones was observed in 20 cases （57.1%） of control group, and 30 cases （85.7%） of experimental group. The difference in the expulsion rate between two groups was statistically significant （ P 〈 0. 05）. Effective cases were 24 in control group, and 32 in experimental group. The difference in the effective rate between two groups was statistically significant （ P 〈 0. 05）. The mean expulsion time and renal colic recurred within 4 weeks were less in experimental group than in control group （ P 〈 0. 05 ）. All patients tolerated the expulsive therapy and no one withdrew. No obvious side effect occurred. Conclusion It is demonstrated that tamsulosin is safe and effective for the management of lower ureteral stones, and it can significantly shorten expulsion time and reduce the rate of renal colic.