针尖化学——化学家的新挑战

Tip Chemistry—— A New Challenge of Chemists

提出针尖化学的概念和围绕这一新概念开展的代表性研究工作。利用功能化的扫描探针显微镜（ＳＰＭ）的针尖，考察自组装膜表面酸碱基团的局域解离性质、测定化学键的强度、聚焦化学反应制备纳米结构等。ＳＰＭ针尖分别起着化学反应的探针、场所和透镜的作用。

A new concept “Tip Chemistry” is proposed,and several representative studies we conducted along with tip chemistry are presented,including using a chemically functionalized scanning probe microscopy(SPM) tip to monitor the local dissociation of surface acid base groups,directly estimating chemical bonding strength by adhesion force measurements,and fabricating nanostructures by localizing chemical reactions with SPM tips.In these studies,a chemically designed SPM tip plays a key role,which serves as the “probe”,the “site”,and the “lens” of chemical reactions,respectively.