摘要
对近期蛋白质工程的工作进行了综合报道，涉及到胰蛋白酶、金属硫蛋白、胰岛素、尿激酶原、组织型纤溶酶原激活剂、ＲＧＤ肽等蛋白质或多肽的结构与功能研究以及分子改造。
Recent developments on protein engineering of some related proteins in our research are introduced.Specificity change,antiautolysis and role of less conserved disulfide bonds of trypsin are demonstrated.Function of single domain and multi copied domains of metallothionein is explained.Studies on intra A chain disulfide bond and C peptide of insulin,chimera of prourokinase and tissue type plasminogen activator,mutation of plasminogen activator inhibitor 1,and RGD containing proteins are also described.
出处
《北京大学学报（自然科学版）》
CAS
CSCD
北大核心
1998年第2期342-349,共8页
Acta Scientiarum Naturalium Universitatis Pekinensis
基金
国家863计划
关键词
蛋白质工程
胰蛋白酶
金属硫蛋白
胰岛素
protein engineering
trypsin
metallothionein
insulin
antithrombotics
protein structure and function
mutant protein
