中药黄芪辅治小儿病毒性心肌炎临床研究

Effect of Radix Astragali on Children with Viral Myocarditis

目的:观察中药黄芪辅治小儿病毒性心肌炎的临床疗效。方法:50例患儿随机分为对照组和治疗组,观察治疗前后临床症状、体征、左室射血(LVEF)、心电图,心肌酶CK-mB、肌钙蛋白I(cTnI)、病毒抗体及免疫功能的变化。结果:与对照组比较,治疗组患儿CK-mB、cTnI降低更明显(P<0.01),心电图恢复更快(P<0.05),心功能改善显著,病毒抗体转阴明显(P<0.05),T淋巴细胞亚群CD3、CD4/CD8较对照组明显升高(P<0.05),CD8较对照组降低(P<0.05),血清免疫球蛋白(IgG、IgA、IgM)较对照组明显升高(P<0.05)。结论:中药黄芪结合传统治疗药物治疗小儿病毒性心肌炎疗效显著,值得临床推广。

Objective： To observe the effect of radix astragali on children with viral myocarditis （VMC）. Methods： Fifty cases were randomly divided into two groups, the control group and the radix astragali treatment group, and clinic symptoms, objective signs, cardiac systolic function （ left ventricular ejection fraction, LVEF）, electrocardiagram （ ECG）, cardiac enzyme （CK-mB） and troponine I （ cTnI）, and anti-Coxsackie virus antibody （IgM） were all determined before and after the treatment. Results： Compared with the those in the control group, clinic symptoms and objective signs were markedly improved, CK-mB, cTnI were significantly decreased （ P 〈 0.01 ）, and ECG improved more quickly （P 〈 0. 05）, LVEF increased in the treatment group ; T lymphocyte subgroups of CD3, CD4, CD4/CD8 increased （ P 〈 0.05 ）, CD8 decreased （ P 〈 0.05 ）, serum immunoglobulins G, A and M increased obviously （ P 〈 0.05 ）. Conclusions ： It is safe and effective to treat the children with viral myocarditis with routine medicine combined with the radix astragali.