辅酶Q10毒理学安全性评价

Toxicology and safety evaluation of coenzyme Q10

目的探讨辅酶Q10毒理学安全性。方法采用小鼠急性经口毒性试验,遗传毒性试验(Ames试验、小鼠骨髓嗜多染红细胞微核试验和小鼠精子畸形试验)及大鼠30d喂养试验,分别观察辅酶Q10的急性毒性、遗传毒性和亚急性毒性。结果辅酶Q10对小鼠的最大耐受剂量(MTD)大于30000mg/kg.BW,遗传毒性试验结果均为阴性;以360、540、720mg/kgBW(分别相当于人体推荐用量的50、75、100倍)3个剂量的样品连续给大鼠灌胃30d,试验期间动物生长发育良好,各剂量组大鼠的体重、增重量、进食量、食物利用率、血常规和生化检测指标、脏器重量及脏器/体重比值与对照组比较,差异均无统计学意义(P>0.05);组织病理学检查,各实验组大鼠肝、肾、胃肠、脾、睾丸和卵巢等组织均未见有病理改变。结论辅酶Q10对动物无明显毒性。

Objective To evaluate the toxicological and safety of coenzyme Q10 . Methods The acute oral toxicity test, inheritance toxicity test include Ames test, polychromatic erythrocytes micronucleus test and sperm malformation test of coenzyme Q10 were carried out in mice and 30-day feeding test in rats was also conducted. Results The acute toxicity of coenzyme Q10 in mice exceeded 30000mg/kg.BW. Inheritance toxicity test were all negative .On 30-day feeding test the rats were fed with sodium hyaluronate at dosage of 360,540 and 720mg/kg.BW for 30 days. During the experiment ther rats grew well and there were no significant differences（P〉0.05） in body weight and food utilization compared with the control group. At the end of the experiment, compared with the contral group, there were also no significant differences （P〉0.05） in blood and biochemical examination, in viscera weight and the ratio of viscera weight to body weight. The histoopathological ehanes in liver, kidney, stomach, intestines, spleen,testicle and ovawy were not observed in every group. Conclusion Coenzyme Q10 is safe to animals.