摘要
目的探讨单硝酸异山梨酯对实验性大鼠胃溃疡的影响。方法采用乙酸造成大鼠胃溃疡模型,50只SD大鼠随机分为5组,即正常对照组、模型组、兰索拉唑(5mg/kg)组、单硝酸异山梨酯高剂量(4mg/kg)组和低剂量(2mg/kg)组,成模3d后开始给药,连续给药14d后处死,然后观察各组大鼠溃疡指数、胃液pH值、病理组织HE染色切片和AB-PAS染色切片。结果与模型组比较,单硝酸异山梨酯高、低二剂量组和兰索拉唑组大鼠胃溃疡指数减低和HE染色显示胃黏膜修复的效果明显,低剂量单硝酸异山梨酯组AB-PAS阳性面积较模型组减少,与正常对照组无差别。结论单硝酸异山梨酯可促进实验性大鼠胃溃疡愈合。
Objective To investigate the effect of isosorbide mononitrate on experimental gastric ulcer in rats. Methods The rat model of gastric ulcer was induced by acetic acid. Fifty SD rats were randomly divided into normal control group, gastric ulcer placebo group, lansoprazole treated control （5mg/kg）, high isosorbide mononitrate dose group （4mg/kg） and low isosorbide mononitrate dose group （2mg/kg）. Forthteen days after treatment,the gastric ulcer tissues were collected for examination of the size and surface area of the ulcer, and stained with HE, AB -PAS.pH of gastric juice were determined. Results Index of gastric ulcer was decreased and HE indicated that gastric mucous membrane were repaired in all treatment group compared with gastric ulcer placebo group. PAS positive in low dose Isosorbide mononitrate treatment group was lower than that in gastric ulcer placebo group , but it was identical to that of normal control group. Conclusion Isosorbide mononitrate can promote the healing of gastric ulcer in rats.
出处
《中国热带医学》
CAS
2009年第2期246-248,共3页
China Tropical Medicine
基金
广东省科技计划项目(编号:2004B30101003)
