氟喹诺酮类药治疗耐药肺结核的效果

Analysis of efficacy of fluoroquinolones in treatment of drug resistant tuberculosis

目的分析及正确评估氟喹诺酮类联合一线抗痨方案在治疗耐药结核病(MDR-PTB)的效果。方法将2003年6月～2007年6月200例MDR-PTB病人随机分为含氟喹诺酮类药治疗组Ⅰ组及不使用氟喹诺酮类药对照组Ⅱ组,疗程为18个月。结果Ⅰ组病人100例92例完成疗程,痰菌阴转86例(93%),Ⅱ组100例96例完成疗程,痰菌阴转49例(52%),痰菌阴转治疗组明显高于对照组(P<0.05),病灶吸收及空洞闭合Ⅰ组病人均优于Ⅱ组。结论含氟喹诺酮类药抗痨方案治疗MDR-PTB效果明显。

Objective To assess the effect of fluoroquinolones in combination with first-line tuberculosis scheme on multidrug-rcsistant TB （MDR-PTB）. Methods There 200 MDR-PTB patients were randomly divided into treatment group consited of 100 patients and treated with fluoroquinolones and control group consisted of 100 patients without fluoroquinolones from June 2003 to June 2007 for course of 18 months. Results There 92 patients in group Ⅰ completed treatment with a sputum negative conversion rate of 93% （86/92）, 96 patients in Group Ⅱ completed treatment with a sputum negative conversion rate of 52%（ 49/92）,showing significant differences. The rate of cavity closure in treatment group was also higher than that of control group. Conclusion The effect of anti-tuberculosis scheme containing fluroquinoloncs on multidrug-resistant TB （MDR-PTB） is significant.