女性年龄与HPV感染、宫颈上皮内瘤变的研究现状

Current status in research of correlation of women's age with HPV infection and canceration of cervical endothelium

子宫颈癌发病趋于年轻化,原因不明。研究发现,年轻女性人乳头状瘤病毒(Human Papillomavirus,HPV)感染和子宫颈上皮内瘤变(Cervical intraepithelial neoplasia,CIN)发生率高,治疗后易复发或持续。女性年龄与HPV感染和CIN的发生、发展密切相关。世界项级癌症中心和发达国家的宫颈癌筛查及管理指南中,确立了年龄别管理策略。我国应加强年龄与HPV感染、CIN相关的数据积累。

The incidence of cervical cancer in young women tends to increasing despite the incidence decreases in population worldwide. Although the specific reasons are still unknown, studies reveal that the incidence of human papillomavirus （HPV）infection and cervical intraepithelial neoplasia （CIN） rate in younger women was higher. CIN in younger woman is easier to relapse. Regarding occurrence and development, women＇s ages are closely related to HPV infection and CIN. In the cervical cancer screening and management guidelines from world top-class cancer centers and the developed countries, there are dearly age-specific management strategies. China should strengthen research and accumulate data about women＇s age and HPV infection regarding cervical precancerous lesions.