经颅超声溶栓联合巴曲酶治疗基底动脉尖综合征临床研究

Clinical study of transcranial ultrasound plus batroxobin thrombolysis in the treatment of patients with top of the basilar syndrome

目的评价经颅超声溶栓联合巴曲酶治疗基底动脉尖综合征的临床效果。方法对19例经MRI证实为基底动脉尖综合征的病人,巴曲酶首次应用剂量为10BU,另两次为5BU,隔日1次,共3次。使用前用250ml生理盐水稀释,静滴1h以上,应用超声溶栓治疗仪(频率800kHz,0.75W/cm,脉冲超声)治疗,2次/d,20min/次,共21d。对治疗前后的疗效进行评定。结果治疗后3周,用NIH-NINDS中风评分量表评分,经颅超声加巴曲酶治疗前得分9.33±1.46,治疗后7.67±1.89,即经颅超声加巴曲酶治疗对神经功能恢复的效果最显著,治疗过程中未见不良反应。结论巴曲酶联合经颅超声溶栓治疗基底动脉尖综合征是一种安全有效的方法,值得临床推广应用。

Objective To study the clinical outcome of transeranial ultrasound plus batroxobin thrombolysis in the treatment of patients with top of the basilar syndrome. Methods Nineteen patients in the treatment of transeranial ultrasound plus batroxobin thrombolysis were confirmed with top of the basilar syndrome by MR1. A dose of batroxobin 10BU dissolved in normal saline 250ml was given by intravenous infusion about 1 hour at first, the other times was 5BU every two days, the totle was three times. Ultrasound （800kHz,0.75W/cm^2 , plus wave）was given twice a day for 14 days. The curative effect was evaluated before and after the treatment. Results Three weeks after the treatment the symptom improvement score in transcranial ultrasound plus batroxobin thrombolysis group was 7.67 ± 1.89, while that before the treatment was 9.33 ±1.46 on the score of the NIH-NINDS. The improvement of neurological deficit in transcranial ultrasound plus batroxobin group was excellent. No other adverse events were available. Conclusion It was a safe and effective method for patients with top of the basilar syndrome in the treatment of transcranial ultrasound plus batroxobin thrombolysis. It was worthy of clinical application and dissemination.