血塞通联合低分子肝素治疗急性脑梗死的临床研究

Clinical Study on Ttreatment of Acute Cerebral Infarction with Xuesetong Injection combined with Low Molecular Weight Heparin

目的观察血塞通与低分子肝素联合治疗急性脑梗死的临床疗效。方法将101例急性脑梗死患者随机分为3组，对照组33例，皮下注射低分子肝素；血塞通组34例，静脉滴注血塞通；治疗组34例，血塞通联合低分子肝素治疗，3组均治疗14d。治疗前后分别进行神经功能缺损评分，血常规、肝功能、。肾功能、凝血功能检查。结果治疗组显效率为71％，有效率为91％，均显著高于对照组和血塞通组（P〈0．05和P〈0．01）。结论低分子量肝素与血塞通联用治疗急性脑梗死有效。

Objective To evaluate the clinical effects of Xuesetong injection combined with Low-molecular-weight Heparin （LMWH） on the treatment of acute cerebral infarction（ACI）. Methods 101 cases of ACI patients were randomly divided into three groups： a group one with thirty-three patients were treated only with 5000 IU LMWH twice daily subcutaneously; a group two with thirty-four patients were treated with only 400 mg Xuesetong injection, one daily by intravenous drip; and a group three with thirty-four patients were treated with enoxaparin and Xuesetong injection. All the three groups were treated for 14 days. Impaired neurological function score, blood routine, functions of liver and kidney, blood coagulating function were examined before and after the treatment. Results Significant effective rate and the effective rate of the group three were 71% and 91% respectively, higher than the other two groups （P〈0.05 or P〈0.01）. No severe adverse reactions were found after the treatment. Conclusion Enoxaparin combined with Xuesetong injection is an effective regimen for the treatment of acute cerebral infarction.