丹参注射液配合复方氨基酸治疗胎儿生长受限的探讨

Investigation on Treatment of Fetal Growth Restriction by Salvia Injection Combined with Composite Amino Acid

目的探讨丹参注射液配合复方氨基酸在治疗胎儿生长受限(fetal growth restriction,FGR)中的作用。方法回顾性分析我院2007年1月-2008年1月临床诊断FGR的孕妇106例,分为两组,治疗组(53例)予丹参注射液配合复方氨基酸治疗;对照组(53例)仅予复方氨基酸。两组均治疗7天,观察临床总有效率、检测脐血流指标。结果(1)治疗组总有效率为81.13%,妊娠24+～28周、28+～32周、32+～36周有效率分别为88.80%(16/18)、80.00%(12/15)、75.00%(15/20);对照组总有效率为69.81%,妊娠24+～28周、28+～32周、32+～36周有效率分别为77.7%(14/18)、66.66%(10/15)、65.00%(13/20),两组比较,差异有统计学意义(P<0.05)。(2)治疗组各孕周治疗后脐动脉收缩期峰值流速和舒张末期血流速度比值降低(P<0.05,P<0.01),对照组治疗前后差异无统计学意义。结论采用丹参注射液配合复方氨基酸治疗FGR能改善胎儿各项指标。

Objective To explore the effect of salvia injection （SI） combined with composite amino acid （CAA） in treating fetal growth restriction （FGR）. Methods A retrospective analysis was conducted on 106 pregnant women with FGR hospitalized from January 2007 to January 2008. Patients were randomized into 2 groups equally, the treated group （53 cases） treated with SI plus CAA, and the control group treated with CAA alone, all for 7 days. The clinical effect and umbilical blood flow （S/D） in patients were observed. Results （ 1 ） The total effective rate in the treated group was 81. 13%, it was 88.80% （16/18） for patients in the gestation period of 24^＋-28 weeks, 80.00% （12/15） for those of 28^＋-32 weeks, and 75.00 （15/20） for32^＋-36 weeks, while in the control group, the corresponding rates were 69.81%, 77.77% （14/18）, 66.66% （10/15）, and 65.00% （13/20）, respectively, The difference between the two groups was significant （P 〈0. 05）. （2） After treatment, S/D significantly lowered in patients of the treated group （ P〈0.05, P〈0.01 ）, no matter how long the gestation period was, but it was insignificantly changed in the control group. Conclusion The combined treatment with SI and CAA on FGR could improve the condition of the fetusl.