脑静脉窦血栓形成的抗凝治疗及预后分析

Anticoagulant Therapy for Cerebral Venous Thrombosis and Prognosis Analysis

目的:观察不同方案的抗凝治疗对于脑静脉窦血栓形成(CVST)的疗效。方法:回顾分析33例应用抗凝治疗的CVST患者,其中静脉控速肝素治疗21例(A组),低分子肝素治疗9例(B组),联合介入溶栓抗凝治疗3例(C组),评价疗效及预后。结果:A、B组的显效时间之间差异有统计学意义(P<0.05)。结论:规范的抗凝治疗能明显提高CVST的治愈率,严格静脉控速肝素与低分子肝素具有相似的抗凝效果,并且出血不良反应无增加。

Objective： To observe the therapeutic effects of anticoagulant therapy with different administration on cerebral venous sinusee thrombosis （CVST）. Methods： The medical records of 33 CVT patients treated with differently introduced anticoagulants were studied and evaluated. Out of the 33 patients, 21 cases received intravenous infusion of regular heparin, while 9 with low molecular Heparin（LMH） and 3 with LMH combined with endovascu- lar treatment. The following parameters have been evaluated： total effective rate, status of intracranial pressur change, MRV and the time window of efficacy. Results： The results showed that there was no significant difference in effective rate among the two groups. Intracranial pressure and MRV revealed no significant changes either. However, the time window of effectiveness was significantly different between the group with intravenous infusion of regular heparin and the group with LMH. Conclusion： The scheduled anticoagulant therapy will significantly influ- ence the improvment rate in patients with CVT. The regular heparin through intravenous infusion at strictly controlled speed shows the approximate effect with LMH.