肿瘤坏死因子与儿童再生障碍性贫血

Tumor Necrosis Factor in Children with Aplastic Anemia

用酶联免疫法检测了22例再生障碍性贫血(急性再障8例、慢性再障14例)患儿血清肿瘤坏死因子(TNF),结果:再障患儿TNF血清浓度为54.14±21.91ng/ml,较正常对照(15名,27.93±9.93ng/ml)明显增高,差异有极显著性意义(P<0.01),且与血小板计数呈负相关,与外周血白细胞计数、血红蛋白量无相关性;急性再障(55.63±28.47ng/ml)较慢性再障(50.14±14.88ng/ml)轻度增高,但差异无显著性意义(P>0.05);输血组TNF为54.10±17.89ng/ml,未输血组TNF为50.50+26.30ng/ml,两组比较差异无显著性意义(P>0.05)。

The level of serum tumor necrosis factor(TNF)in 22 children with aplastic anemia (acute in 8, chronic in 14)were determined by ELISA. The results showed that the level of serum TNF in children with aplastic anemia was 54. 14±21.91ng/ml,was significantly higher than that in controls (27. 93±9. 93ng/ml) , the difference between then being statistically significant(P<0.01). The level of serum TNF in the childern with aplastic anemia was negatively related to platelet count (r=0.5044), not to WBC count and hemoglobin content. The level of serum TNF level in the children with acute aplastic anemia was mildly higher than that in chronic aplastic anemia cases without statistical difference(P>0. 05).