p53蛋白在胆囊腺癌中的表达及意义

Expression and significance of p53 protein in adenoearcinoma of the gallbladder

应用免疫组织化学Ｓ·Ｐ法检测了４２例胆囊腺癌和８例胆囊腺瘤中ｐ５３蛋白（突变型）的表达情况。结果显示，胆囊腺癌中ｐ５３阳性率为４７．６％，胆囊腺瘤及癌旁正常粘膜阳性率均为０％，与胆囊腺癌比较，差异有显著性（Ｐ＜０．００５）。ｐ５３在胆囊低分化腺癌中阳性表达率明显高于高分化腺癌（Ｐ＜０．０５），ｐ５３基因的突变或过表达是胆囊腺癌发生发展过程中常见的基因事件。

42 cases of gallbladder adenocarcinoma were examined to observe the expression of p53 oncoproteins with immunohistochemical staining method (sp method).The positive expression for p53 were 476%.The adenomas and normal mucosa were uniformly negative.The results were signifieantly different when compared to cancer tissue(P<0005).p53 positive rate was significantly higher in poorly differentialed cancer than in highly differentialed cholecystic cancer(P<005).It was suggested that p53 may be used as a good marker relating to the prognosis.