肝硬化患者血细胞内氨基酸检测的临床研究

A Clinical Study On the Measurement of AA in Blood Cells of Cases With Liver Cirrhosis

采用日立８３５－５０型高速自动氨基酸分析仪，测定肝硬化患者血细胞内氨基酸。结果显示：１．肝硬化红细胞内天门冬、缬、异亮、亮和组氨酸降低；丝、谷、甘、酪、苯丙、精和脯氨酸明显增高。（Ｐ＜０．０５）２。肝硬化白细胞内氨基酸谷、缬、亮和脯氨酸降低，苏、丝、丙、异亮、苯丙、酪、组和精氨酸增高。（Ｐ＜０．０５）３。肝硬化血细胞支／芳比值与血浆相同均降低，但红细胞内有５种氨基酸增高使总量增加２０７．８６μｍｏｌ／Ｌ；白细胞有１３种增高３０２．６８μｍｏｌ／Ｌ。提示血细胞在调整氨基酸代谢过程中起重要作用。

To study the characteristics of the changes of blood cell Amino-acids(AA) with patients of liver cirrhosis,measurement of blood cell AA in 33 cases with liver cirrhosis was reported in this paper,and 30 normal cases were studied as controls.The results show:Compared with the normal,the concentration of AA inside red or white blood cells in cases of cirrhosis changes significantly(P<005),showing that AA function differently in different parts of the body,so the concentration in blood cells and serum differs accordingly,It also indicates,in the adjustment of AA metabolism,the blood cell is the major factor,and its action contrariety from serum at some respects.