乙肝后肝硬化患者血清和腹水中白细胞介素-6、肿瘤坏死因子α水平的观察

The levels of IL6 and TNFα in serum and ascites from patients with cirrhosis after hepatitis B

本文检测５０例乙型肝炎后肝硬化患者腹水和血清中白细胞介素６（ＩＬ－６）、肿瘤坏死因子α（ＴＮＦα）的含量。结果显示：血清和腹水ＩＬ－６、ＴＮＦ－α水平均显著高于正常（Ｐ＜０．０５或０．０１）。腹水感染者血清和腹水ＩＬ－６、ＴＮＦα水平高于非感染者（Ｐ＜０．０１或０．００１），当感染控制后血清和腹水ＩＬ－６、ＴＮＦα水平仅能降至非感染者水平而不能恢复正常。结果揭示，ＩＬ６、ＴＮＦα参与肝炎后肝硬化病理发展过程并在腹水的形成中发挥作用。检测血清和腹水ＩＬ６、ＴＮＦα值变化对肝硬化腹水合并腹腔感染的诊断。

The levels of IL6 and TNFα in serum and ascites were detected in 50 patients with cirrhosis after hepatitis B.It showed that the levels of IL6 and TNFα in serum and ascites were higher than normal(P<005 or 001) and were higher in patients with ascites infection than in no infection (P<001 or 0001).The levels decreased to the condition of no infection but not to the normal while infection was controled.It is suggested that IL6 and TNFα participate in the course of cirrhosis developing and play a role in the ascites forming.It can be helped to diagnose abdominal cavity infection and to determime treatment effect by detection serum and ascites value of IL6 and TNFα.