复发性阿弗他溃疡患者淋巴细胞抑制功能的改变

The changes of suppressor T cells function in patients with RAU

目的探索复发性阿弗他溃疡（ｒｅｃｕｒｒｅｎｔａｐｈｔｈｏｕｓｕｌｃｅｒ，ＲＡＵ）患者Ｔ淋巴细胞的抑制功能。方法应用刀豆碱（ｃｏｎｃａｎａｖａｌｉｎＡ，ＣｏｎＡ）激活产生的淋巴细胞抑制检测法探查了１２例溃疡期患者外周血淋巴细胞的抑制活性。结果患者溃疡期的Ｔ淋巴细胞抑制率在ＣｏｎＡ为１、２、４和８ｍｇ／Ｌ时，分别是６０％、４０％、２７％和２０％，明显低于正常组的７２％、５６％、４１％和３４％（Ｐ＜０．０５）。结论ＲＡＵ患者外周血Ｔ淋巴细胞的抑制功能可能出现暂时性降低。

Objective To study the change of suppressor T cell function in patients with RAU. Methods Samples of 12 patients with RAU active phase were studied by it suppressor assay. Results The T cell suppress rates at ConA 1,2,4 and 8 mg/L were 60%, 40%, 27% and 20% respectively, and were evidently lower when compared with normal controls′ 72%, 56%, 41% and 34% ( P < 0.05 ). Conclusion The suppressor T cell function may be depressed in RAU patients.