TNF-α在伴有血管病变的NIDDM患者胰岛素抵抗发生中的意义

THE ROLE OF TUMOR NECROSIS FACTORα IN INSULIN RESISTANT OF PATIENTS WITH NON-INSULIN DEPENDENT DIABETES MELLITUS ACCOMPANYING DIABETIC ANGIOPATHY

为探讨肿瘤坏死因子－α在伴有血管病变的Ⅱ型糖尿病患者胰岛素抵抗发生中的意义，采用放射免疫法检测了４０例Ⅱ型糖尿病患者血清肿瘤坏死因子－α水平，比较其在伴有或无血管并发症的Ⅱ型糖尿病患者中的差别并分析其与胰岛素敏感性的关系。结果显示，伴有血管并发症的Ⅱ型糖尿病患者血清肿瘤坏死因子－α含量明显高于无血管并发症的Ⅱ型糖尿病患者，且与胰岛素敏感性呈负相关。提示肿瘤坏死因子－α在胰岛素抵抗发生中起重要作用。

The level of tumor necrosis factorα(TNFα) were measured in 40 patients with noninsulin dependent diabetes mellitus(NIDDM) accompanying diabetic angiopathy or not in order to study their correlation with insulin resistantThe evaluated level of TNFα were found in NIDDM patients with angiopathy and associated with the insulin resistant. The results indicated that the TNFα play a role in insulin resistant of NIDDM patients with angiopathy.