胃泌素及其受体拮抗剂对胃癌BGC-823细胞系p53基因蛋白表达的影响

The Effect of Gastrin and Gastrin Receptor Antagonist on the Expression of p53 Protein in BGC823 Cell Line

胃泌素是胃肠道Ｇ细胞分泌的一种多肽激素，对胃肠道粘膜细胞及某些恶性肿瘤细胞有显著促生长作用，这种作用可被其受体拮抗剂Ｌ－３６５２６０所阻断。本实验用胃泌素－１７及其受体拮抗剂Ｌ－３６５２６０分别或单独对ＢＧＣ－８２３细胞系作用７２ｈ后，发现胃泌素对细胞ｐ５３基因蛋白的表达普遍有促进作用，而Ｌ－３６５２６０对ｐ５３的表达却表现为明显抑制。这一结果提示胃泌素和／或Ｌ－３６５２６０可能参与了细胞的增殖或转化过程。

The effect of gastrin and L365260 on human gastric carcinoma cell line BGC823 with conjunction to the expression of mutated p53 protein was studied.The results indicate that p53 protein levels were markedly upregulated in response to gastrin treatment, but it could be inhibited by L365260.