宫颈癌中c-erbB-2蛋白表达及临床意义

Clinical Significance of cerbB2 OncoproteinExpression in Cervical Carcinoma

为了探讨ｃ－ｅｒｂＢ－２蛋白在宫颈癌中的表达及其临床意义，用免疫组化ＡＢＣ法观察了１０例正常宫颈组织，１６例慢性宫颈炎组织，１２３例宫颈鳞癌中ｃ－ｅｒｂＢ－２蛋白表达。结果显示：宫颈鳞癌中ｃ－ｅｒｂＢ－２阳性表达（３４．１５％）显著高于正常（０／１０）及炎症组织（１８．７５％）（Ｐ＜０．０１），且ｃ－ｅｒｂＢ－２表达随临床期别升高而增加，其中Ⅲ期（５５．３６％）显著高于０期（０／３）、Ⅰ期（７．６９％）、Ⅱ期（１９．６１％）（Ｐ＜０．０１）；ｃ－ｅｒｂＢ－２蛋白表达与宫颈癌分化程度及存活率呈负相关。结果提示，ｃ－ｅｒｂＢ－２蛋白过度表达可能作为判断宫颈癌恶性程度及预后指标之一。

To study the pattern of expression and clinical significance of cerbB2 protein in cervical carcinoma, we assayed the expression of cerbB2 in 10 normal tissues, 16 chronic cervicitis and 123 cervical suqamous cell carcinomas by ABC immunohistochemical staining. cerbB2 positive rate was significantly higher in carcinomas (34.15%) than normal cervical tissues (0/10) and cervicitis (18.75%, P<0.01).In cervical carcinoma,expression of cerbB2 was elevated parallelling the escalation of the clinical stage. In stage III disease it was markedly higher (55.36%) than those in stage 0 (0/3), stage I (7.69%), stage II (19.61%, P<0.01). The expression of cerbB2 protein coorelated reversely with the cellular differentiation of cervical carcinoma and the patients survival. The results suggest that expression of cerbB2 may be used as one of the prognostic markers.