新生儿硬肿症患儿SOD、T_4、TSH的变化及相关关系探讨

Study of the changes of SOD, T_4, TSH in cases of neonatal scleredema and their relations

对比观察了21例正常儿和19例新生儿硬肿症患者血清超氧化物歧化酶（SOD）、四碘甲状腺素（T4）及促甲状腺激素（TSH）含量的变化，并将三项指标进行相关分析。结果发现：硬肿症患儿SOD活性及T4含量明显低于对照组（P均＜0．001）；TSH含量与正常组相比无统计学差别；硬肿症患儿SOD活性与T4含量呈正相关（r＝0．581，P＜0．01），T4与TSH无相关性（r＝－0．257，P＞0．05）。提示：自由基的损伤作用及甲状腺功能低下参与该病的病理生理过程；T4的下降可能是由于自由基损伤甲状腺所致。

The changes of the superoxide dismutase(SOD), tetraiodothyronine(T4 ), and thyroid- stimulating hormone(TSH)were compared in 19 cases of neonotal slceredema with 21 healthy newborns,and the relations between the above-mentioned figures were analysed. The results showed that the serum SOD activity and the T4 level in the neonatal seleredema group were significantly lower than those in the normal group(P <0. 001);however, there was no statistically significant difference between the serum TSH levels in the both groups. There was a positive correlation between the serum SOD activity and the T4 level(r = 0. 581, P <0.01)and a zero correlation between the serum T4 level and the TSH level (r = -0. 257, P > 0.05) inthe neonatal scleredema group. The results suggest that the injury caused by free radical and thyropenia may take part in the pathophysiological process of neonatal scleredema; the low level of serum T4 may be a result of thyroidea injurp caused by free radical