马钱子碱的药代动力学

Pharmacokinetic study on brucine

用荧光分光光度法测定马钱子碱（B）在小鼠体内的血药浓度及其药代动力学参数。结果表明：小鼠尾静脉注射3种剂量10，7．5和5mg·kg－1的B后时量曲线均符合二室开放模型。其主要动力学参数：分别为0．17，0．22和0．16h；分别为1．96，2．11和2．06h；Vc分别为7．23，7．59和5．65L·kg－1；AUC分别为2．48，1．96和1．45h·mg·L－1；CLs分别为4．03，3．82和3．44L·h－1·kg－1。此法为人体内的药代动力学研究提供了实验方法。

A spectrophotofluorometric method for determination of brucine concentration in blood and its pharmacokinetic parameter in mice was established. After brucine was iv administered at the doses of 10,7. 5and 5 mg·kg-1 to mice, the curve of blood concentration-time was shown in accordance with an open two-compartment model. The pharmacokinetic parameters of the three doses were as follows: were 0. 17,0.22 and 0. 16 h; were 1 .96,2. 11 and 2.06 h; Vc were 7.23,7.59 and 5.65 L·kg-1; AUC were 2.48,1.96 and 1. 45 h·mg· L-1; CLs were 4. 03, 3. 82 and 3. 44 L·h-1·kg-1, respectively. This method provides basis for clinical pharmocokinetics study.