基质金属蛋白酶抑制剂-2在贲门癌患者血清和肿瘤组织中的表达及其临床意义

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摘要我们应用酶联吸附免疫和免疫组织化学染色分别检测了40例贲门癌患者的术前血清和术后标本中基质金属蛋白酶抑制剂（TIMP）-2的表达，探讨TIMP-2在贲门癌发生发展中的作用，以及TIMP-2在术前血清和术后标本中表达的关系。

作者周博冯笑山王公平高社干张广平邢鲁奇米建强马志坤郝曙光侯建峰陈强茹艺

机构地区河南科技大学第一附属医院肿瘤科河南科技大学肿瘤研究所河南科技大学第一附属医院病理科

出处《中华实验外科杂志》 CAS CSCD 北大核心 2009年第2期259-259,共1页 Chinese Journal of Experimental Surgery

关键词基质金属蛋白酶贲门癌癌患者抑制剂-2 临床意义肿瘤组织血清金属蛋白酶抑制剂

分类号 R735.2 [医药卫生—肿瘤]

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1李莉,张声,林华,林建银.基质金属蛋白酶和组织金属蛋白酶抑制剂表达失衡与胃癌浸润转移的关系[J].癌症,2002,21(3):305-310. 被引量：57
2Grigon D J, Sakr W, Toth M. High levels of tissue inhibitor of metalloproteinase-2 (TIMP-2) expression are associated with poor outcome in invasive bladder cancer. Cancer Res, 1996,56 : 1654-1659.
3万兴旺,王红阳,何雅琴,刘淑琴,曹慧芳,邱秀华,唐亮,吴孟超.细胞内基质金属蛋白酶-2/细胞内基质金属蛋白酶组织抑制剂-2在PTEN抑制肝癌细胞粘附及浸润迁移中的作用[J].中华实验外科杂志,2003,20(6):508-510. 被引量：5
4杨锦建,张秋红,贾占奎,周四维.基质金属蛋白酶(MMP)9、MMP2 mRNA及基质金属蛋白酶抑制剂2 mRNA在人膀胱移行细胞癌中的表达及意义[J].中华实验外科杂志,2006,23(4):594-595. 被引量：33

二级参考文献18

1万远廉,戎龙,刘玉村,汪欣,吴涛,潘义生,姚宏伟,叶京明,汤坚强,朱静.组织因子对大肠癌侵袭能力的影响及其与基质金属蛋白酶-9的关系[J].中华实验外科杂志,2004,21(9):1087-1088. 被引量：17
2程波,仇登波,帅晓明,李治.乳腺癌中HER2基质金属蛋白酶-2和9的表达及其相互关系[J].中华实验外科杂志,2004,21(12):1513-1514. 被引量：9
3Tian XX,Pang JC,To SS,et a1.Restoration of wild-type PTEN expression leaads to apoptosis,induces differentiation,and reduces telomerase activity in human gliomas cells.J Neuropathol Exp Neurol,1999,58:472-479.
4Gesbert F,Sellers WR,Signoretti S,et a1.BCR／ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kipl through the phosphatidylinositol 3-Kinase／AKT pathway.J Biol Chem,2000,275:39223-39230.
5LaFlamme SE,Thomas LA,Yamada SS,et a1.Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization,cell spreading and migration,and matrix assembly.J Cell Biol,1994,126:1287—1298.
6Inagaki K,Yamao T,Noguchi T,et a1.SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility.EMBO J,2000,19:6721-6731.
7Chesler L, Golde DW, Bersch N, et al. Metalloproteinase inhibition and erythroid potentiation are independent activities of tissue inhibitor of metalloproteinases-1 [J]. Blood, 1995, 86: 4506-4515.
8Aznavoorian S, Murphy AN, Stetler Stevenson WG, et al. Molecular aspects of tumor cell invasion and metastasis [J]. Cancer, 1993, 71:1368-1383.
9Ramos DeSimone N, Hahn Dantona E, Sipley J, et al. Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion [J]. J Biol Chem, 1999, 274(19):13066-13076.
10Goldverg GJ, Strongin A, Collier IE, et al. Interaction of 92 kDa type Ⅳ collagenase with tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase and activation of proenzyme with stromelysin [J]. J Biol Chem, 1992, 267:4583-4591.