强化降脂治疗的临床策略及应用

Clinical strategy and application on intensive lipid-lowering treatment

大量研究证实强化降脂治疗能阻断或逆转动脉粥样硬化病变进展。目前认为,对于急性冠脉综合征患者的强化治疗时间至少应坚持2年。而稳定型冠心病也需大幅度降低胆固醇。但需要认识到大幅度降低胆固醇的潜在危害和局限性,降脂不是越低越好,同时也要监测可能发生的不良反应。

Summary： The massive researches confirmed intensive lipid-lowering therapy can block or reverse the progress of atherosclerosis. At present it has been believed that the term of intensive therapy should remain at least for 2 years in the patients with acute coronary syndrome. Significant reduction in the cholesterol is also essential for the patients with stable coronary heart disease. It should be realized that markedly lowering the cholesterol has latent damage and limitation. Lower lipid level does not mean better status. The adverse effects are also need to be monitored simultaneously.