25例新疆维吾尔族IgA肾病与HLA—DR4、DR12相关性研究

Relationship of hla-dr gene and IgA nephropathy in Xinjiang Uygur population

目的研究人类白细胞Ⅱ类抗原（HLA—DR4、DR12）与新疆维吾尔族IgA肾病的相关性。方法采用聚合酶链反应-序列特异性引物法（PCR-SSP）对25例新疆维吾尔族IgA肾病及50例正常对照组的HLA-DR4、DR12基因频率进行检测。结果①新疆维吾尔族IgA肾病组的HLA—DR4基因频率高于对照组（P〈0．01）；②新疆维吾尔族HLA—DR12基因频率IgA肾病组较正常对照组无明显差异；③新疆维吾尔族HLA-DR4、DR12基因阳性IgA肾病患者的临床表现及病理预后指标与新疆维吾尔族HLA-DR4、DR12基因阴性者比较无明显差异。结论HLA-DR4基因可能是新疆维吾尔族IgAN的易感基因。

Objective To study relationship between of HLA Ⅱ （ HLA-DR4, DR12） and Xinjiang Uygur IgA nephropathy. Methods HLA-DR4 and HLA-DR12 genes in 25 cases of IgA neph ropathy pat-ients and 50 normal controls were investigated by Polymerse Chain Reaction-Sequence Specific Primers （PCR-SSP）technique. Results ①The frequency of HLA-DR4 gene in IgA nephropathy patients was higher than that in normal controls（P 〈0. 01 ） ;②Xinjiang Uygur HLA-DR12 gene frequency of IgA nephropathy group is no difference of the control group ;③The clinical manifestation and pathologic features have no difference between HLA-DR4, DR12 positive and negative IgAN patients. Conclusion HLA-DR4 gene may be susceptible allele in patients with IgA neperopathy in Xinjiang Uygur population.