肠内营养在重症急性胰腺炎的临床应用

The role of enteral nutrition in treatment of severe acute pancreatitis

目的研究肠内营养（EN）在治疗重症急性胰腺炎（SAP）中所起的作用。方法收集2006年1月至2008年8月本院收治的重症急性胰腺炎患者33例，16例接受经鼻空肠管肠内营养＋肠外营养（EN＋PN）治疗，17例接受全肠外营养（TPN）治疗，比较两组患者症状改善情况、生化指标恢复时间、细菌或真菌培养阳性率、住院天数、住院费用的差异。结果经鼻空肠管肠内营养＋肠外营养（EN＋PN）比全肠外营养（TPN）症状体征改善、生化指标恢复及住院时间显著缩短、细菌或真菌培养阳性率显著降低，住院费用明显减少（均P〈0．05）。结论EN＋PN应用于重症急性胰腺炎卓有成效，经济，安全可行，值得临床推广。

Objective To investigate the role of enteral nutrition on treatment of severe acute pancreatitis. Methods A total of 33 patients with SAP, admitted between January 2006 and August 2008, While EN ＋ PN group consisted of 16 patients receiving enteral nutrition through nose-jejunum tube and parenteral nutrition （EN ＋ PN）therapy, TPN group consisted of 17 patients receiving TPN therapy. Major causes, treatments and clinical results were analyzed and the incidence of infections, the length of hospital stay, the costs were compared between two groups. Results Compared with TPN group, EN ＋ PN group was associated with a lower incidence of infections, enteral nutrition shortened the hospital stay and saved the cost （P 〈 0. 05）. Conclusion EN combined with PN is an effective, economic and safe way in treatment of severe acute pancreatitis.