摘要
目的探讨骨髓细胞抗体放散试验在免疫相关性血细胞减少症诊断中的敏感性和实用价值。方法对28例临床疑诊为免疫相关性血细胞减少症的患者进行骨髓单个核细胞直接抗人球蛋白试验（BMMNC-Coombs）和骨髓细胞抗体放散试验。结果BMMNC-Coombs检出的骨髓造血细胞自身抗体的阳性率为50．0％，骨髓细胞抗体放散试验检出的阳性率为85．7％，后者显著高于前者，（r=8．187P〈0．005）。骨髓细胞抗体放散试验检测自身抗体阳性的24例患者中含IgG型20例占83．3％，含IgM型21例占87．5％，含IgA型16例占66．7％，含C3型10例占41．7％。结论骨髓细胞抗体放散试验敏感性高于BMMNC-Cooms试验。
Objective To explore the sensitivity and diagnostic values of antibody elution test of bone marrow cells in patient with immunorelated hemoeytopenia. Methods 28 patients with uncertain immunorelated hemoeytopenia were investigated by using direct antihuman globulin reaction（eoombs-test） of bone marrow cells （BMMNC） and antibody elution test of bone marrow cells. Results The positive rate of antibody elution test of bone marrow cells was 85.7%which was higher than that by BMMNC-Coombs test（50. 0% ） （X^2 = 8. 187 P 〈 0. 005）. In 24 positive cases, 20 （83.3%） with IgG autoantibody, 21 （87. 5% ） with lgM autoantibody, 16 （66. 7% ） with lgA autoantibody, 10 （41.7 % ） with C3 autoantibody. Conclusion The sensitivity of antibody elution test of bone marrow cells was higher than that of BMMNC-Coombs test for detecting autoantibodies.
出处
《中国临床实用医学》
2009年第1期50-52,共3页
China Clinical Practical Medicine
