1453例住院患者抗菌药物临床应用回顾性调查分析

Clinical Antibiotics Usage among Inpatients:A Retrospective Survey and Analysis of 1453 Cases

目的了解抗菌药物应用现状并进行综合分析,以便采取相应的管理对策。方法根据设计调查表对某医院2005年12月-2006年1月1453份出院病历,按照统一的方法和标准进行抗菌药物应用情况回顾性调查。结果1453例住院患者中1155例使用抗菌药物,使用率为79.5%;其中单独用药占47.3%、二联占44.1%、三联占7.4%、≥四联占1.2%;抗菌药物使用率排在前5位的科室依次为口腔科、烧伤科、普外科、儿科、呼吸科;抗菌药物使用种类以头孢菌素类为主,其次为硝基咪唑类和含酶抑制剂类;不合理应用主要表现为无指征用药、选药起点较高及疗程不合理等。结论抗菌药物临床应用存在严重的不合理现象,应加强相关知识的培训,制定切实可行的监督和管理措施,确保合理使用抗菌药物。

OBJECTIVE To investigate the clinical application of antimicrobial agents and give corresponding analysis. METHODS Totally 1453 cases from Dec 2005 to Jan 2006 were investigated retrospectively according to questionaire, and the usage of antibiotics was analyzed according to the standards. RESULTS Among 1453 cases, 1155 cases used antibiotic and accounted for 79.5 %, of which 47.3 % cases were for single-drug therapy, 44.1 cases for dual-drug therapy, 7. 4% cases were for tri-drug therapy and 1. 2% cases for more than four kinds drugs. The top five departments in usage amount of antibiotics were stomatology, burn, surgery, pediatrics and respiratory departments. The most common antibiotics were cephalosporins, nitromidazole and catastaltica containing enzymes. The main irrational application of antibiotics included medication without indication, using high standard medicine and illogicality course of treatment and so on. CONCLUSIONS The application of antibiotics in internal medicine still has some irrational phenomenon, therefore, the training of correlated knowledge and regulations should be strengthened.